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Summary and Miscellaneous

In summary, ensure adequate production of hydrochloric acid by restoring zinc levels, or supplement Betaine hydrochloride. Supplement with digestive enzymes (SpectraZyme™, EnZym-Complete™, Peptizyde™/Hn-Zyme Prime™, or GI-Zyme™ by Mannatech™. This will improve nutrient status. Next, supplement a good multiple/vitamin mineral. I suggest GlycoBears® (chewable) for children (Mannatech, Inc.). It contains 26 vitamins and minerals (no iron) in a base of 30 fruits and vegetables and rice syrup. Most basic to the child’s recovery is the glyconutrient, Ambrotose AO, and the Phytonutrient Phyt•Aloe® in the form of Manna•Bears™, a delicious, pectin gummy in bear form. These would be the basic five. Additionally, a high intake of vitamin B6, magnesium, and zinc with balancing amounts of vitamins B1 and B2 would be strongly recommended. The anti-viral/bacterials Lauricidin™ and Colostrum would be welcome additions with additional supplements as indicated: fatty acids and amino acids to meet the need.

The foremost thing you should attempt here is to restore thyroid function that controls enzyme production of the pancreas. That will require you restore iodine, selenium, zinc, vitamin A, glutathione, and tyrosine to high-normal levels. Reduction of fluoride, excess copper, mercury, and other heavy metals may be needed. Make the Iodine and the Barnes’ Morning Temperature tests, and if these indicate, follow the suggestions to restore the thyroid function. These kids are highly stressed, and need adrenal support as indicated. It is imperative that you give any nutritional intervention at least three month’s time, faithfully followed, before judging it ineffective. Six months is more realistic for some may not show visible improvements any sooner. No attempt to increase nutrient level is wasted. The body will use these nutrients to some benefit whether you “see” it or not. Coincidentally, you should use digestive enzymes, Yeast Avenger™ or other antifungal, and high-count acidophilus: GI-Pro™ (Mannatech™), ProCulture Gold™ (Kirkman) to control Candida and trash bacteria that have overrun the “Good Guys” in the gut. If your child is PST, however, you should not attempt to clear Candida and bacterial overgrowth until you have reduced his toxic load by unloading the donkey, otherwise, your child may suffer Kyle’s experience. Do a homeopathic, vaccine detoxication that removes mercury and aluminum as well as other poisons pumped into your child with vaccines. Medically, of first importance, test for heavy metal poisoning and chelate as indicated, however, do not chelate unless you are sure the mineral levels are normal, especially, do not chelate medically if selenium, zinc, magnesium, manganese, and/or molybdenum are low.

The Specific Carbohydrate Diet (SCD) or a casein/gluten free diet has been of great help to many; however, the problem with the SCD is that it makes some artificial distinctions that end up limiting its effectiveness while complicating it unnecessarily. Although the basics of this diet are sound, it is best adjusted for each individual case. In some instances, the complete elimination of all grains is simply unnecessary, while for others, foods that are freely allowed in the SCD, such as honey, fruit, or nuts, should be restricted to achieve optimal results. Similarly, the GF/CF diet tends to become another high-carbohydrate diet when the need is for protein. In eliminating casein, you eliminate the child’s major protein source. This is one reason a change to SCD works better for some; it restores a source of protein. Additionally, selenium supplied through breakfast cereals, cakes, and biscuits, and in view of its high bioavailability, wheat-selenium (Se) probably supplies around half the Se one intakes, this being so, a gluten free diet is a selenium deficient one.

If on a gluten free diet, the following is pertinent:

It is important to know that Lactase enzyme supplement (Dairy Ease™) had gluten in both their tablet and drop forms. Furthermore, Gas-X™ (simethicone), Pepcid™ (Famotidine), Tagamet™ (Cimetidine) also contained gliadin. Karoly Horvath, M.D., Ph.D. Associate Professor of Pediatrics, University of Maryland at Baltimore Tel: 410-328-0812 Fax: 410-328-1072. Prilosec™ is reported to contain lactose.

I have other suggestions for controlling parasites and yeast. Feel free to send me any questions you may have, there is no obligation, and the counsel is free.

I have not charged for this extensive work, or for hours and hours of counsel, because I know so many cannot afford this needed help, but for those of you who can, please send a gift so that I may continue this needed work. OK? You may also wish to purchase my e-book, “Self-help to Good Health”, 50 Chapters, over 1000 Pages, $29.95 US. A list of Chapter Titles may be seen at To access it you will need to join my Autism List. Payment or contributions to PayPal:

Willis S. Langford

3579 Santa Maria Street

Oceanside, CA, 92056 USA (The science of glyconutrients) (Information on Mannatech™ products and business venture, and buy glyconutrients at retail prices) (Autism List) My Ebook sales site My Health Page blog (under construction) (Pharmacists trained in glyconutritionals and drug usage/interactions, diabetes counseling. etc.) or (760) 439-7884 (for free counseling)

Contributions to PayPal: Revised 5/28/11

I am not a medical professional. Nothing herein is intended to prescribe for, or to treat disease, but is intended to inform, and to recommend certain courses of action that may be viable to investigate further. In every instance, it is advised that these actions be undertaken with the advice and consent of your medical professional. Feel free to share this paper with him. Email it to him or put it on CD.

Acknowledgments: I wish to acknowledge and thank Kathy Blanco, of Beaverton, Oregon, USA ( for introducing me to the Internet experience of counseling autism, and who has provided sources for much of what I have brought to you. Polly Hattemar has contributed much over the years to my knowledge and understanding. I also wish to acknowledge and thank Paula Reza, of Scotland, UK, for her suggestion that I write this type of paper, and for her insightful and helpful encouragement, and for many of the ideas included. It was she who introduced me to the condition labeled PST, and asked my help in addressing it. I appreciate Audrey Adams, of Renton, Washington, for her contributions to this paper and to the Autism List, Williss. I thank all three for the openness and willingness to try many of my suggestions, and to share many of their successful interventions that I have included. I appreciate, too, their willingness to introduce these ideas to friends in the autism community. I’m happy to report that their children have responded remarkably well to many of the ideas included herein. Andy Cutler, and Jeff Clark of Metals Board at, and numerous others have contributed bits and pieces. Credit is given to the following who were not interviewed, but the quotes are faithfully taken from their published literature: Susan Owens for her valuable contributions to my understanding of GAGs, CCK, and Motilin. (From the 1998 Durham Conference “Psychobiology of Autism”: Explorations of the New Frontier between Gut and Brain: A look at GAGs, CCK and Motilin by Susan Costen Owens, University of Texas at Dallas,; to Patricia Kane, BodyBio Centre, 45 Reese Road, Millville, NJ 0833 for her information on fatty acids; to Dr. Robert J. Sinaiko, MD, for quotes from his paper “The Biochemistry of Attentional/Behavioral Problems”, to Henry Osiecki, B Sc (Hons) Grad Dip Nutr Diet, to Dr. Woody McGinnis. MD, formerly of Tucson, Arizona, to Dr. Mary Megson, to Bernard Windham, Chemical Engineer, to Dr. Doris Rapp, MD, and to Vijendra Singh, Ph.D., Utah State University, Logan, Utah for the quotes herein; however, none of these may agree with the final product :-). I thank also Jon and Polly Tommey of England for publishing an earlier version of this paper as a bound insert in the third edition (Spring 2000) of their remarkable magazine, “The Autism File” ( My contribution was to put it all into a useable format as an aid to suffering mothers who have been left largely without guidance in this troubling malady.

These additional sources are recommended:

From a compilation by Dr. Woody McGinnis formerly of Tucson, Arizona.

  • Gastrointestinal Abnormality:

  • Malabsorption (J. Autism/Childhood Schizo, 1971 1(1):48-62)

  • freq. reports acholic stools (lack of bile), undigested fibers, positive Sudans (undigested fat test).

  • 85% of autistic meet criteria for malabsorption (B.Walsh, 500 pts)

  • Maldigestion--elevated urinary peptides:

  • P Shattuck (Brain Dysfunct 1990; 3: 338-45 and 1991; 4: 323-4)

  • KL Reicheldt (Develop Brain Dys 1994; 7: 71-85, and others)

  • Z Sun and R Cade (Autism 1999; 3: 85-96 and 1999; 3: 67-83)

  • Microbial Overgrowth--fungal, bacterial and viral: William Shaw, Biological Basis of Autism and PDD, 1997. E Bolte on Clostridium (Med Hypoth, 1998; 51: 133-144). P. Shattock and A. Broughton: IAG elevations. W. Walsh and W. McGinnis: pyrrole elevations. Andrew Wakefield, (Lancet 1998; 351: 637-4), TJ Borody, Center for Digestive Diseases, New S. Wales, Australia.

  • Abnormal Intestinal Permeability: P D’Eufemia (Acta Pediatr 1995; 85; 1076-9) G.I. Symptoms reported by parents: diarrhea, constipation, gas, belching, probing, visibly undigested food, and need for rubs.

  • Compromised immunity:

  • Recurrent Infections:

  • Euro Child/Adolesc Psych, 1993:2(2):79-90

  • J Autism Dev Disord 1987; 17(4): 585-94

  • Abnormal Indices:

  • T-cell Deficiency (J Autism Child Schizo 7:49-55 1977)

  • Reduced NK Cell Activity (J Ann Acad Chil Psyc 26: 333-35 ‘87)

  • Low or absent IgA (Autism Develop Dis 16: 189-197 1986)

  • Low C4B levels (Clin Exp Immunol 83: 438-440 1991)

  • Skewed (“elevated”) Viral Titers increasing grass-roots reports V Singh University of Michigan

  • Detoxification Weakness:

  • Phase II Liver Enzymes, Depression (S. Edelson, DAN Conference Sept, 1997, and Toxicology and Industrial Health 14 (4): 553-563 1998)

  • Sulphation low in 15 of 17 (mean 5 vs. nl 10-18)

  • Glutathione Conjugation low in 14 of 17 (mean 0.55 vs 1.4-2.9)

  • Glucuronidation low in 17 of 17 (mean 9.6 vs. 26.0-46.0)

  • Glycine Conjugation low in 12 of 17 (15.4 vs. 30.0-53.0)

  • Sulphation Deficit (Biol Psych 1; 46(3): 420-4, 1999)

  • Peroxisomal Malfunction (P Kane, J of Orthomolec Med 1997; 12-4: 207-218 and 1999; 14-2: 103-109)

  • Higher blood lead levels in Autism and documented response to EDTA Chelation (Am J Dis Chld 130: 47-48, 1976)

  • Apparent temporal association autism onset and lead exposure (Clinical Pediatrics 27: 1; 41-44 1988)

  • Abnormal Nutritional Profile in Children with Autism:

  • Lower serum Magnesium than controls (Mary Coleman, The Autistic Syndromes 197-205, 1976)

  • Lower RBC Magnesium than controls (J. Hayek, Brain Dysfunction, 1991)

  • Low activated B6 (P5P) in 42%. Autistic group also higher in serum copper. (Nutr. and Beh 2:9-17, 1984)

  • Low EGOT (functional B6) in 82% and all 12 subjects low in 4 amino acids (tyrosine, carnosine, lysine, and lysine hydroxylysine).

  • Dietary analysis revealed below-RDA intakes in Zinc (12 of 12 subjects), Calcium (8 of 12),

  • Vitamin D (9 of 12), Vitamin E (6 of 12) and Vitamin A (6 of 12) (G. Kotsanis, DAN Conf., Sept, 1996) B6 and Magnesium therapeutic efficacy--multiple positive studies (start with Am J Psych 1978; 135: 472-5)

  • Low Derivative Omega-6 RBC Membrane Levels 50 of 50 autistic assayed through Kennedy Krieger had GLA and DGLA below mean. Low Omega-3 less common (may even be elevated) (J Orthomolecular Medicine Vol 12, No. 4, 1997)

  • Low Methionine levels not uncommon (Observation by J. Pangborn)

  • Below normal glutamine (14 of 14), high glutamate (8 of 14) (Invest Clin 1996 June; 37(2): 112-28) Higher Copper/Zinc ratios in autistic children. (J. Applied Nutrition 48: 110-118, 1997)

  • Reduced sulphate conjugation and lower plasma sulphate in autistic. (Dev. Brain Dysfunct 1997; 10:40-43)

  • B12 deficiency suggested by elevated urinary methylmalonic acid (Lancet 1998; 351: 637-41)

  • Hypocalcinurics Improve with Calcium Supplementation, Lower Hair Calcium in Autistics Reported (Dev Brain Dysfunct 1994; 7: 63-70).

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